Metabotropic Glutamate Receptor 4
ExpressMAX™ Expression-ready Human GPCR ORF Clones
Product Overview:
Metabotropic Glutamate Receptor 4 is a member of the GPCR family and is encoded in Humans by the GRM4 gene. GRM4, GRM6, GMR7 and GRM8 belong to group III of the metabotropic glutamate receptor. L-glutamate is the major excitatory neurotransmitter in the Central Nervous System and activates both ionotropic and metabotropic glutamate receptors. These receptors inhibit of the cyclic AMP cascade. Activation of GRM4 has potential therapeutic benefits in the treatment of Parkinson´s disease. Taste GRM4 is involved in the perception of umami.
Quote requestAvailability: In stock! Ready-to-ship immediately
Catalog Numbers, Sizes & Prices
| Cat. No. | Size | Price |
| G0560-B | Bacterial Stock | 289 € |
| G0560-Plus | 15 µL (12-well plate) + 0.2 mL | 667 € |
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Different specifications, sizes or Bulk Orders? please visit Custom Solutions or OEM partnerships.
Note: Prices may vary between countries, because additional cost may be applied due taxes, shipments or Custom fees.
Advantages & Features
- Native structure.
- Wide range: a large collection of ExpressMAX™ GPCR ORF Clones availables.
- Highest levels of GPCR expression: on surface cell lines, > 50% of TAG detection by cytometry.
- Wide spectrum: of strong constitutive promoters.
- Complete solution: it contains all necessary elements for maximum receptor expression.
- Ready-to-use solution: avoids cloning steps, DNA ready to transfect.
- Easy protocol and detection: the whole procedure is simple, with minimal handling.
- Neomycin resistance.
- Ampicillin bacterial selection.
Specifications
- Plasmid size: 8227 bp
- Promoter: pCMV
- ORF Sequence (GenBank based): NM_000841
- Protein Sequence (SwissProt): Q14833
- Bacterial Selection Antibiotics: Ampicillin
- Mammalian Selection Antibiotic: Neomycin
- Alternative names: mGlu4, MGLUR4, MGC177594, GPRC1D mGlu4, GPRC1D or MGLUR4
Includes
Includes:
ExpressMAX™ GPCR ORF Clones (Cat. No. – B)
– Vector as transformed Bacteria in stab culture or a Glycerol Stock format.
Mammalian Transfection Kits (Cat. No. – PLUS):
– 15 µg ExpressMAX™ Mammalian Expression Vector (1 mg/mL).
– 0.2 mL CANFAST™ Transfection Reagent.
Download documentation
BrochureApplications
- Functional assays, as protein immobilization, cellular localization and other functional assays.
- High-throughput and large scale protein production and purification.
- Reverse transfection arrays and nucleic acid programmable protein arrays (NAPPA).
Quality Control
The quantity and quality of purified DNA is checked by:
- Ratio 260/ 280.
- Agarose gel electrophoresis.
- Digestion with restriction endonucleases.
Storage, Shipping & Guarantee
- Shipped in: Dry Ice.
- Storage: ExpressMAX™ GPCR ORF Clones (-20 ºC) and CANFAST™ (4 ºC).
- Shelf Life: 24 months from the date of purchase, if it is properly stored.
Safety Statements
This product is developed, designed and sold exclusively for Research purposes and in vitro use only (RUO). The product was not tested for use in diagnostics or for drug development, nor is it suitable for administration to humans or animals. For more info, please check its Material Safety Data Sheet available in this website.
